N. M. Pearce

Of Problems and Opportunities - How to Treat and How to not Treat Crystallographic Fragment-Screening Data

The paper shows that properly treated crystallographic fragment-screening data do not suffer from the criticisms raised by Jaskolski et al.

A method for intuitively extracting macromolecular dynamics from structural disorder

This paper introduces a method to decompose structural disorder into hierarchical contributions, enabling better understanding of macromolecular dynamics from B-factors and alternative conformations.

Implications for tetraspanin-enriched microdomain assembly based on structures of CD9 with EWI-F

The paper presents crystal and cryo-EM structures of CD9 with nanobodies and EWI-F, revealing a tetrameric arrangement that provides a model for tetraspanin-enriched microdomain assembly.

New routes for PTP1B allosteric inhibition by multitemperature crystallography, fragment screening and covalent tethering

The paper identifies a new allosteric site in PTP1B using multitemperature crystallography and fragment screening, showing covalent tethering can inhibit enzyme activity.

Gentle, fast and effective crystal soaking by acoustic dispensing

The paper describes a high-throughput method for crystal soaking using acoustic droplet ejection, showing it is gentle, fast, and effective for generating protein-ligand complexes.