Author

T. J. Sharpton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:metagenomics· 6 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Approach:experimental assay· 2 Organism:zebrafish· 2 Research Focus:benchmarking· 1 Research Focus:clustering· 1

Frequent Co-Authors

C. A. Gaulke· 3 shared E. Ho· 3 shared C. Armour· 2 shared C. Gaulke· 2 shared H. K. Arnold· 2 shared I. R. Humphreys· 2 shared R. L. Tanguay· 2 shared B. M. Tyler· 1 shared

Activity by Year

2017-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersMicrobiology

C. A. Gaulke

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Age and micronutrient effects on the microbiome in a mouse model of zinc depletion and supplementation

E. W. Davis, C. P. Wong, H. K. Arnold, K. Kasschau, C. A. Gaulke, T. J. Sharpton, E. Ho

This study examines how age and zinc diet affect the gut microbiome in mice, finding age has a stronger impact than zinc status on microbiome composition.

bioRxiv · Sep 16, 2022Microbiology

Chronic clinical signs of upper respiratory tract disease shape gut and respiratory microbiomes in cohabitating domestic felines.

H. K. Arnold, R. Hanselmann, S. M. Duke, T. J. Sharpton, B. R. Beechler

The study examines how chronic upper respiratory tract disease in cats affects their gut and nasal microbiomes, finding microbial differences associated with clinical signs.

bioRxiv · May 9, 2022 · PreprintMicrobiology

Evaluation of the effects of library preparation procedure and sample characteristics on the accuracy of metagenomic profiles

C. Gaulke, E. R. Schmeltzer, M. Dasenko, B. M. Tyler, R. Vega Thurber, T. J. Sharpton

This study evaluates how different metagenomic library preparation methods affect the accuracy of microbial community profiles across various sample types and DNA amounts.

bioRxiv · Apr 12, 2021Microbiology

Pseudocapillaria tomentosa, Mycoplasma spp., and intestinal lesions in experimentally infected zebrafish Danio rerio

M. Kent, E. S. Wall, S. Sichel, V. Watral, K. Stagman, T. J. Sharpton, K. Guillemin

This study investigates the role of Mycoplasma spp. and Pseudocapillaria tomentosa in causing intestinal lesions and neoplasms in zebrafish through experimental infections.

bioRxiv · Nov 8, 2020Cancer Biology

Interspecies comparative metagenomics reveals correlated gut microbiome functional capacities among vertebrates

C. A. Gaulke, C. R. Armour, I. R. Humphreys, L. M. Beaver, L. Carbone, E. Ho, R. L. Tanguay, Y. Jiang, T. J. Sharpton

This study compares gut metagenomes across 10 vertebrate species to identify conserved and variable microbial functional pathways, showing general similarity to human gut microbiomes but with notable differences in disease-related pathways.

bioRxiv · Jun 15, 2020 · PreprintMicrobiology

An integrated gene catalog of the zebrafish gut microbiome reveals significant homology with mammalian microbiomes

C. A. Gaulke, L. Beaver, C. Armour, I. R. Humphreys, C. Barton, R. L. Tanguay, E. Ho, T. J. Sharpton

The paper constructs a zebrafish gut microbiome gene catalog, showing significant homology with human and mouse microbiomes despite taxonomic differences.

bioRxiv · Jun 15, 2020 · PreprintMicrobiology

Development of Inflammatory Bowel Disease is Linked to a Longitudinal Restructuring of the Gut Metagenome in Mice

T. J. Sharpton, S. Lyalina, J. Luong, J. Pham, E. M. Deal, C. Armour, C. Gaulke, S. Sanjabi, K. S. Pollard

This study uses longitudinal metagenomic analysis in a mouse model of IBD to identify microbial functional changes linked to disease progression and immune activation.

bioRxiv · Aug 10, 2017Microbiology