Author

T. J. Silhavy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:E. coli· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Assay:proteomics· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

B. K. Hammer· 1 shared I. V. Mikheyeva· 1 shared J. Sun· 1 shared K. A. MacGillivray· 1 shared K. Huang· 1 shared R. L. Guest· 1 shared S. L. Ng· 1 shared S. Wiesenfeld· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperEvolutionary Biology

B. K. Hammer

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2 papers

Recent·Most cited

Mechanism of outer membrane destabilization by global reduction of protein content

I. V. Mikheyeva, J. Sun, K. Huang, T. J. Silhavy

This study investigates how reducing outer membrane protein content in Gram-negative bacteria weakens the outer membrane, alters cell shape, and causes rupture by disrupting lipid asymmetry.

bioRxiv · Feb 19, 2023Microbiology

Trade-offs constrain adaptive pathways to T6 survival

K. A. MacGillivray, S. L. Ng, S. Wiesenfeld, R. L. Guest, T. Jubery, T. J. Silhavy, W. C. Ratcliff, B. K. Hammer

This study uses experimental evolution to show that Escherichia coli evolves resistance to Vibrio cholerae's Type VI Secretion System (T6) through specific mutations, but these mutations come with fitness costs.

bioRxiv · Sep 2, 2022Evolutionary Biology