Chemical Systems Biology Reveals Mechanisms of Glucocorticoid Receptor Signaling
N. Bruno, J. C. Nwachukwu, S. Srinivasan, C. C. Nettles, T. Izard, z. Jin, S. Boregowda, D. Phinney, O. Elemento, X. Liu, E. A. Ortlund, R. Houtman, D. Stavreva, G. Hager, T. Kamencka, , K. W. Nettles
The paper uses Ligand Class Analysis to identify target genes and coregulator interactions of glucocorticoid receptor ligands, revealing mechanisms linking ligand structure to physiological outcomes.
bioRxiv · Jun 15, 2020Pharmacology & Toxicology