Author

C. C. Nettles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:metabolomics· 1

Frequent Co-Authors

J. C. Nwachukwu· 2 shared K. W. Nettles· 2 shared R. Houtman· 2 shared S. Srinivasan· 2 shared T. Izard· 2 shared B. Katzenellenbogen· 1 shared B. Pascal· 1 shared D. Kojetin· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCancer Biology

J. C. Nwachukwu

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2 papers

Recent·Most cited

Dual mechanism estrogen receptor inhibitors

J. Min, J. C. Nwachukwu, S. Srinivasan, E. Rangarajan, C. C. Nettles, V. Sanabria Guillen, Y. Ziegler, S. Yan, K. Carlson, Y. Hou, S. H. Kim, S. Novick, B. Pascal, R. Houtman, P. Griffin, , K. W. Nettles

This paper develops dual-mechanism ER inhibitors that use two distinct targeting moieties to suppress ER activity in breast cancer cells and resistance models.

bioRxiv · Jul 6, 2020Cancer Biology

Chemical Systems Biology Reveals Mechanisms of Glucocorticoid Receptor Signaling

N. Bruno, J. C. Nwachukwu, S. Srinivasan, C. C. Nettles, T. Izard, z. Jin, S. Boregowda, D. Phinney, O. Elemento, X. Liu, E. A. Ortlund, R. Houtman, D. Stavreva, G. Hager, T. Kamencka, , K. W. Nettles

The paper uses Ligand Class Analysis to identify target genes and coregulator interactions of glucocorticoid receptor ligands, revealing mechanisms linking ligand structure to physiological outcomes.

bioRxiv · Jun 15, 2020Pharmacology & Toxicology