Ubiquitin ligase RIPLET mediates polyubiquitination of RIG-I and LGP2 and regulates the innate immune responses to SARS-CoV-2 infection
T. Kouwaki, T. Nishimura, G. Wang, R. Nakagawa, H. Oshiumi
This study identifies RIPLET as a ubiquitin ligase that activates RIG-I signaling and modulates innate immune responses to SARS-CoV-2 by polyubiquitinating RIG-I and LGP2.
bioRxiv · Jan 25, 2021 · PreprintImmunology