R. Nakagawa

Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitis

This study shows LOX promotes epithelial differentiation and barrier integrity in EoE by activating the BMP pathway through increased BMP2 and reduced follistatin.

Epi-microRNA mediated metabolic reprogramming ensures affinity maturation

This study identifies miR-155's role in metabolic reprogramming of GC-B cells to support affinity maturation under hypoxic conditions.

Regulation of BCR-mediated Ca2+ mobilization by MIZ1-TIMBIM4 safeguards IgG1+ GC B cell positive selection

This study identifies MIZ1-TMBIM4 as a mechanism safeguarding IgG1+ GC B cell positive selection by regulating Ca2+ mobilization and preventing mitochondrial dysfunction.

mTORC1 activity is essential for disease progression in chronic lymphocytic leukemia

This study shows that mTORC1 is essential for CLL progression in mice, with rapamycin effectively targeting eEF2 to inhibit proliferation and MCL1 expression.

The ESX-1 secretion system senses bacterial contact and prepares mycobacteria for environmental adaptation

The paper shows the ESX-1 system in mycobacteria senses bacterial contact and environmental nitrogen levels, regulating secretion and adaptation.

Combinatorial immunotherapies overcome MYC-driven immune evasion

This study shows that MYC-driven immune evasion in TNBC can be reversed by combining immunotherapies, leading to tumor regression in mice.

Transient induction of cell cycle promoter Fam64a improves cardiac function through regulating Klf15-dependent cardiomyocyte differentiation in mice

This study shows that transient activation of Fam64a improves cardiac function in adult mice by promoting cardiomyocyte proliferation without excessive dedifferentiation.

Seven amino acid types suffice to reconstruct the core fold of RNA polymerase

The paper reconstructs the DPBB fold using only seven amino acid types, suggesting it could have emerged with the early genetic code.

Ubiquitin ligase RIPLET mediates polyubiquitination of RIG-I and LGP2 and regulates the innate immune responses to SARS-CoV-2 infection

This study identifies RIPLET as a ubiquitin ligase that activates RIG-I signaling and modulates innate immune responses to SARS-CoV-2 by polyubiquitinating RIG-I and LGP2.

ES-62 suppression of arthritis reflects epigenetic rewiring of synovial fibroblasts to a joint-protective phenotype

This study shows ES-62 induces an epigenetic protective phenotype in synovial fibroblasts by remodelling their DNA methylome, potentially offering new therapeutic strategies for rheumatoid arthritis.

Identification of bridgin, an unconventional linker, connects the outer kinetochore to centromeric chromatin

The paper identifies bridgin, a new linker protein in fungi, that connects the outer kinetochore to centromeric chromatin, differing from known linker proteins.

A large inner membrane pore defines the ESX translocon

The paper reports the cryo-EM structure of the ESX-3 secretion system, revealing a large pore capable of translocating folded substrates and a regulatory cytoplasmic complex.