Induced antigen-binding polyreactivity in human serum IgA
E. N. Gorshkova, M. Lecerf, I. V. Astrakhantseva, E. A. Vasilenko, O. V. Starkina, N. A. Ilyukina, P. A. Dimitrova, J. D. Dimitrov, T. L. Vassilev
The paper shows that human IgA can acquire polyreactivity when exposed to acidic pH, heme, or ferrous ions, increasing reactivity to bacterial and viral antigens.
bioRxiv · Sep 29, 2021Immunology