Author

J. D. Dimitrov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:proteomics· 7 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1

Frequent Co-Authors

M. Lecerf· 6 shared C. Planchais· 3 shared A. Kanyavuz· 2 shared A. Reyes-Ruiz· 2 shared H. Mouquet· 2 shared R. V. Lacombe· 2 shared A. C. Ferguson-Smith· 1 shared A. Zarantonello· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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6 shared papersImmunology

M. Lecerf

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Temperature sensitivity of bat antibodies links metabolic state with antigen-recognition diversity

N. Toshkova, V. Zhelyzkova, A. Reyes-Ruiz, E. Haerens, M. de Castro Deus, R. V. Lacombe, M. Lecerf, G. Gonzalez, N. Jouvenet, C. Planchais, J. D. Dimitrov

This study shows that bat antibodies change their antigen-binding properties with temperature, linking metabolic state to immune diversity and anti-inflammatory function.

bioRxiv · Aug 14, 2023Immunology

Polyreactivity of antibodies from different B cell subpopulations is determined by distinct sequence patterns of variable region

M. Lecerf, R. V. Lacombe, J. D. Dimitrov

The paper identifies sequence patterns in antibody variable regions that determine polyreactivity across different B cell subpopulations and shows distinct patterns for each subpopulation.

bioRxiv · Jul 22, 2023Immunology

Post-translational regulation of the Numb/Notch pathway in neurogenesis and cancer by Dlk2

S. B. Telerman, R. S. Hamilton, B. Shaw, J. D. Dimitrov, B. Steventon, A. C. Ferguson-Smith

This study identifies Dlk2 as a regulator of Numb/Notch pathway in zebrafish neurogenesis and human cancer, showing its role in modulating Numb phosphorylation and Notch signaling.

bioRxiv · Jul 20, 2023 · PreprintCell Biology

Evolutionary trajectory of receptor binding specificity and promiscuity of the spike protein of SARS-CoV-2

C. Planchais, A. Reyes-Ruiz, R. Lacombe, A. Zarantonello, M. Lecerf, M. Revel, L. T. Roumenina, B. P. Atanasov, H. Mouquet, J. D. Dimitrov

The paper investigates how the SARS-CoV-2 spike protein's interaction with ACE2 evolved, revealing changes in binding dynamics and physicochemical forces across variants.

bioRxiv · Jun 11, 2022Biochemistry

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

C. Planchais, I. Fernandez, T. Bruel, G. Dias de Melo, M. Prot, M. Beretta, P. Guardado-Calvo, J. Dufloo, L. M. Molinos-Albert, M. Backovic, J. Chiaravalli, E. Giraud, B. Vesin, L. Conquet, L. Grzelak, , H. Mouquet

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

bioRxiv · Apr 1, 2022Immunology

Induced antigen-binding polyreactivity in human serum IgA

E. N. Gorshkova, M. Lecerf, I. V. Astrakhantseva, E. A. Vasilenko, O. V. Starkina, N. A. Ilyukina, P. A. Dimitrova, J. D. Dimitrov, T. L. Vassilev

The paper shows that human IgA can acquire polyreactivity when exposed to acidic pH, heme, or ferrous ions, increasing reactivity to bacterial and viral antigens.

bioRxiv · Sep 29, 2021Immunology

Interaction of clinical-stage antibodies with heme predicts their physiochemical and binding qualities

M. Lecerf, A. Kanyavuz, S. Rossini, J. D. Dimitrov

The paper shows that clinical-stage antibodies interacting with heme have specific sequence traits and functional qualities that predict therapeutic failure.

bioRxiv · Aug 4, 2020Immunology

Method for identification of heme-binding proteins and quantification of their interactions

N. Bozinovic, R. Noe, A. Kanyavuz, M. Lecerf, J. D. Dimitrov

This paper introduces an immunosorbent assay for identifying heme-binding proteins and quantifying their interactions with minimal protein amounts.

bioRxiv · Dec 17, 2019Biochemistry