T. Lechler

Compartment specific responses to contractility in the small intestinal epithelium

This study investigates how increased actomyosin contractility affects different compartments of the small intestinal epithelium, revealing distinct cellular responses in villi and crypts.

Maf Family Transcription Factors are Required for Nutrient Uptake in the Neonatal Gut

This study identifies MafB and cMaf as transcription factors essential for neonatal gut nutrient uptake, showing their role in endo-lysosomal programs and metabolic pathway changes.

KIF18B is a cell-type specific regulator of spindle orientation in the epidermis

This study identifies KIF18B as a regulator of spindle orientation in keratinocytes, linking microtubule dynamics to cell fate decisions during hair follicle development.

Mechanical Regulation of Stem Cell Proliferation and Fate Decisions by their Differentiated Daughters

The paper shows that differentiated epidermal cells regulate stem cell behavior through mechanical signals, affecting proliferation, fate, and migration.

Ndel1 promotes keratin assembly and desmosome stability

This study identifies Ndel1 as a desmosome-associated protein that promotes keratin assembly and desmosome stability in epidermal cells.

Proteomic analysis of the desmosome identifies novel components required for skin integrity

The paper identifies novel desmosome components through proteomic analysis, showing their dependence on desmoplakin and their role in epidermal integrity.

Regulated spindle orientation buffers tissue growth in the epidermis

The paper shows that spindle orientation regulates asymmetric cell divisions to buffer tissue growth in mammalian skin, preventing overgrowth or loss.

A transgenic toolkit for visualizing and perturbing microtubules reveals unexpected functions in the epidermis

The paper develops a genetic toolkit to study microtubule dynamics in vivo, revealing novel roles in epidermal development and morphogenesis.