W. Ning

Compartment specific responses to contractility in the small intestinal epithelium

This study investigates how increased actomyosin contractility affects different compartments of the small intestinal epithelium, revealing distinct cellular responses in villi and crypts.

ARHGAP32 as a novel RhoGAP interacting with desmoplakin is required for desmosomal organization and assembly

This study identifies ARHGAP32 as a RhoGAP interacting with desmoplakin, essential for desmosomal organization and epithelial cell sheet integrity by regulating actomyosin contractility.

The TRIP6/LATS1 complex constitutes the tension sensor of α-catenin/vinculin at both bicellular and tricellular junctions

This study identifies TRIP6 and LATS1 as novel components of the tension sensor complex at bicellular and tricellular junctions, revealing their distinct distribution and dynamics compared to α-catenin/vinculin.

Pan-cancer quantification of neoantigen-mediated immunoediting in cancer evolution

This study quantifies neoantigen-mediated immunoediting stages in cancer evolution across tumor types, showing elimination and escape signals predict immunotherapy response.

Environmental response in gene expression and DNA methylation reveals factors influencing the adaptive potential of Arabidopsis lyrata

The paper examines how environmental factors influence gene expression and DNA methylation in Arabidopsis lyrata, revealing plasticity and genetic variation in response to lowland and alpine conditions.

Extrachromosomal DNA is associated with decreased immune cell infiltration and antigen presentation, represents a potential cancer immune evasion mechanism

This study shows that extrachromosomal DNA (ecDNA) is linked to reduced immune cell infiltration and antigen presentation, suggesting it helps cancer cells evade immune surveillance.

Mechanical Regulation of Stem Cell Proliferation and Fate Decisions by their Differentiated Daughters

The paper shows that differentiated epidermal cells regulate stem cell behavior through mechanical signals, affecting proliferation, fate, and migration.

Constructing an ethanol utilization pathway in Escherichia coli to produce acetyl-CoA derived compounds

This paper engineers Escherichia coli to convert ethanol into acetyl-CoA and its derivatives through a heterologous pathway, achieving efficient ethanol consumption and production of PHB and prenol.