BiochemistrybioRxiv
Cooperative Cobinding of Synthetic and Natural Ligands to the Nuclear Receptor PPARγ
J. Shang, R. Brust, S. A. Mosure…·D. J. Kojetin
The paper shows synthetic and natural ligands can bind cooperatively to PPARγ, altering its structure and function through a 'ligand link' to the omega loop.
DOI 10.7554/elife.43320