Cancer BiologybioRxivPreprint
ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells
C. Bergonzini, A. Gregori, T. M. S. Hagens…·E. H. J. Danen
This study identifies ABCB1 overexpression via locus amplification as a conserved mechanism of paclitaxel resistance in PDAC and shows that targeting ABCB1 can sensitize resistant cells to treatment.
DOI 10.1101/2023.05.30.542412