Author

T. M. Zaniewski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

W. O. Hancock· 3 shared A. M. Gicking· 2 shared E. M. Ostap· 1 shared J. Fricks· 1 shared S. Pyrpassopoulos· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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3 shared papersCell Biology

W. O. Hancock

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3 papers

Recent·Most cited

The net charge of the K-loop regulates KIF1A superprocessivity by enhancing microtubule affinity in the one-head-bound state

T. M. Zaniewski, W. O. Hancock

This study shows that the net charge of the K-loop in KIF1A enhances microtubule affinity in the one-head-bound state, increasing run length and processivity.

bioRxiv · Aug 21, 2022 · PreprintCell Biology

KIF1A is kinetically tuned to be a super-engaging motor under hindering loads

S. Pyrpassopoulos, A. M. Gicking, T. M. Zaniewski, W. O. Hancock, E. M. Ostap

This study uses optical tweezers to show KIF1A generates higher force and sustains longer attachment under hindering loads compared to KIF5B, with rapid microtubule reengagement.

bioRxiv · May 16, 2022 · PreprintBiophysics

The fast and superprocessive KIF1A predominately resides in a vulnerable one-head-bound state during its chemomechanical cycle

T. M. Zaniewski, A. M. Gicking, J. Fricks, W. O. Hancock

This study elucidates the chemomechanical cycle of KIF1A, revealing that it predominantly resides in a one-head-bound state during its cycle, with fast rear head detachment and tethered head attachment as key rate-limiting steps.

bioRxiv · Jun 28, 2020Cell Biology