Author

T. Maniatis

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Biology Disciplines

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Cell Biology· 1

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

C. S. Evans· 1 shared E. L. F. Holzbaur· 1 shared J. Cheung· 1 shared J. Ye· 1 shared O. Harding· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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1 shared paperCell Biology

C. S. Evans

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1 paper

Recent·Most cited

ALS and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy

O. Harding, C. S. Evans, J. Ye, J. Cheung, T. Maniatis, E. L. F. Holzbaur

This study examines how ALS and FTD-linked TBK1 mutations affect mitophagy, revealing that both TBK1 recruitment and kinase activity are necessary for mitochondrial clearance, with some mutations causing mitochondrial stress and others having limited impact.

bioRxiv · Apr 12, 2021Cell Biology