J. Cheung

Long-term epidemiology and evolution of swine influenza viruses in Vietnam

The paper tracks the long-term epidemiology and evolution of swine influenza viruses in Vietnam, identifying gene pool enrichment and reassortment events.

Epigenetic reprogramming of DCCs into dormancy suppresses metastasis via restored TGFβ-SMAD4 signaling.

The paper shows that AZA+atRA treatment induces dormancy in DCCs by restoring TGFβ-SMAD4 signaling, suppressing lung metastasis.

ALS and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy

This study examines how ALS and FTD-linked TBK1 mutations affect mitophagy, revealing that both TBK1 recruitment and kinase activity are necessary for mitochondrial clearance, with some mutations causing mitochondrial stress and others having limited impact.

EZH2 Abundance Regulated by UHRF1/UBE2L6/UBR4 Ubiquitin System is the Potential Therapeutic Target to Trigger Pigmented Phenotype in Melanoma

The paper identifies the UHRF1/UBE2L6/UBR4 ubiquitin system as a regulator of EZH2 abundance, which controls pigmentation in melanoma by influencing melanin biosynthesis.

Counterfactual Hypothesis Testing of Tumor Microenvironment Scenarios Through Semantic Image Synthesis

The paper introduces a generative model to test hypotheses about cell-cell interactions in tumor microenvironments using synthetic multiplexed images.

NINJA: an inducible genetic model for creating neoantigens in vivo

The paper develops a genetic model called NINJA to create inducible neoantigens in mice, enabling controlled T cell responses without central tolerance.

T cell co-stimulatory receptor CD28 is a primary target for PD-1-mediated inhibition

This study shows PD-1 inhibits T cell activation by preferentially dephosphorylating CD28 over TCR, revealing CD28 as a primary target for PD-1-mediated suppression.