E. L. F. Holzbaur

Spastin locally amplifies microtubule dynamics to pattern the axon for presynaptic cargo delivery

This study identifies spastin's role in enhancing microtubule dynamics to pattern axons for presynaptic cargo delivery in human neurons.

RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors

This study shows that hyperactive LRRK2 impairs synaptic vesicle precursor trafficking by phosphorylating RAB3A, leading to disrupted synaptic protein delivery and potential non-motor PD symptoms.

Axonal transport of autophagosomes is regulated by dynein activators JIP3/JIP4 and ARF/RAB GTPases

The paper investigates the regulation of axonal autophagosome transport by dynein activators JIP3/JIP4 and ARF6/RAB10 GTPases, showing their roles in motor complex formation and organelle trafficking.

The selective autophagy receptor p62 and the heat shock protein HSP27 facilitate lysophagy via the formation of phase-separated condensates

This study identifies p62 and HSP27 as key regulators of lysophagy by forming phase-separated condensates at damaged lysosomes, linking their dysfunction to ALS pathogenesis.

Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling

The paper identifies NEMO recruitment to damaged mitochondria as a mechanism linking impaired mitophagy to NF-κB activation and inflammation.

Spatiotemporal analysis of axonal autophagosome-lysosome dynamics reveals limited fusion events trigger two-step maturation

The paper uses a quantitative model to analyze axonal autophagosome-lysosome dynamics, revealing limited fusion events and a two-step maturation process.

Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway

The paper identifies sequential dynein effector handoffs during axonal autophagosome transport and maturation, showing their role in motility and neuronal health.

Structural Basis for Membrane Recruitment of ATG16L1 by WIPI2 in Autophagy

This study determines the crystal structure of WIPI2 interacting with ATG16L1, revealing the molecular mechanism of ATG16L1 recruitment to the phagophore and its role in autophagy initiation.

ALS and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy

This study examines how ALS and FTD-linked TBK1 mutations affect mitophagy, revealing that both TBK1 recruitment and kinase activity are necessary for mitochondrial clearance, with some mutations causing mitochondrial stress and others having limited impact.

Kinesin-4 Motor Teams Effectively Navigate Dendritic Microtubule Arrays Through Track Switching and Regulation of Microtubule Dynamics

This study shows KIF21B kinesin-4 motors navigate mixed polarity microtubules in dendrites through directional switching and microtubule dynamics regulation.

Cega: A Single Particle Segmentation Algorithm to Identify Moving Particles in a Noisy System

The paper introduces Cega, a single particle segmentation algorithm that improves particle tracking in noisy systems by using KL divergence to distinguish moving particles from background noise.