Epigenomic profiling discovers trans-lineage SOX2 partnerships driving tumor heterogeneity in lung squamous cell carcinoma
T. Sato, S. Yoo, R. Kong, M. Fridrikh, A. Sinha, P. Chandramani-Shivalingappa, A. Patel, O. Nagano, T. Masuko, M. B. Beasley, C. A. Powell, J. Zhu, H. Watanabe
This study identifies two distinct LUSC subtypes driven by Sox2 partnerships with Brn2 or p63, revealing lineage heterogeneity and potential therapeutic targets.
bioRxiv · Jun 12, 2019Cancer Biology