APOL1 Variant-Expressing Endothelial Cells Exhibit Autophagic Dysfunction and Mitochondrial Stress
A. Blazer, Y. Qian, M. P. Schlegel, J. Buyon, K. Cadwell, M. Cammer, S. Heffron, F.-X. Liang, S. Mehta-Lee, T. Niewold, S. Rasmussen, R. Clancy
This study shows that APOL1 risk variants in endothelial cells impair mitochondrial function, lysosome integrity, and autophagy, with IFN-gamma exacerbating these effects in heterozygous cells.
bioRxiv · Mar 18, 2020Cell Biology