F.-X. Liang

Sample preparation and data collection for Serial Block Face Scanning Electron Microscopy of Mammalian Cell Monolayers

The paper describes protocols for preparing and imaging mammalian cell monolayers using SBF-SEM, including embedding methods and data collection optimization.

Endocytic vesicles act as vehicles for glucose uptake in response to growth factor stimulation

The paper shows that glucose uptake via GLUT1 co-endocytoses with PDGF receptor upon PDGF stimulation, delivering glucose to mitochondria for glycolysis.

3D reconstructions of parasite development and the intracellular niche of the microsporidian pathogen E. intestinalis

This study uses 3D imaging to analyze the development of the microsporidian E. intestinalis and its interaction with host cell mitochondria.

Bacterial contact induces polar plug disintegration to mediate whipworm egg hatching

This study identifies how bacterial contact triggers polar plug disintegration in whipworm eggs, facilitating larval hatching through chitinase activity rather than bacterial enzymes.

ACE2-containing defensosomes serve as decoys to inhibit SARS-CoV-2 infection

The paper identifies ACE2-containing exosomes, termed defensosomes, that inhibit SARS-CoV-2 infection by binding and blocking viral entry.

Murine GFP-Mx1 forms phase-separated nuclear condensates and associates with cytoplasmic intermediate filaments: novel antiviral activity against vesicular stomatitis virus

3-Dimensional Organization and Dynamics of the Microsporidian Polar Tube Invasion Machinery

This study investigates the 3D structure and dynamics of the microsporidian polar tube invasion machinery using microscopy techniques, revealing high-speed ejection and nuclear deformation during infection.

APOL1 Variant-Expressing Endothelial Cells Exhibit Autophagic Dysfunction and Mitochondrial Stress

This study shows that APOL1 risk variants in endothelial cells impair mitochondrial function, lysosome integrity, and autophagy, with IFN-gamma exacerbating these effects in heterozygous cells.

Human antiviral protein MxA forms novel metastable membrane-less cytoplasmic condensates exhibiting rapid reversible \"crowding\"-driven phase transitions

This study shows that the human antiviral protein MxA forms metastable cytoplasmic condensates that undergo rapid reversible phase transitions in response to osmotic changes.

PHASE TRANSITIONED NUCLEAR OSKAR PROMOTES CELL DIVISION OF DROSOPHILA PRIMORDIAL GERM CELLS

The paper investigates nuclear germ granules in Drosophila PGCs, showing Oskar drives their formation and function in cell division.