Casein kinase 1D encodes a novel drug target in Hedgehog-GLI driven cancers and tumor-initiating cells resistant to SMO inhibition
E. Peer, S. K. Aichberger, F. Vilotic, G. Wolfgang, T. Parigger, S. Grund-Groeschke, D. P. Elmer, F. Rathje, A. Ramspacher, M. Zaja, S. Michel, S. Hamm, F. Aberger
This study identifies CSNK1D as a novel therapeutic target in Hedgehog-GLI driven cancers, showing its inhibition reduces tumor-initiating cell growth in both SMO-sensitive and -resistant settings.
bioRxiv · Jun 17, 2021Cancer Biology