S. Michel

Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia

This study develops an improved method to measure CFTR drug responses in nasal airway organoids derived from 2D differentiated epithelial cells.

Casein kinase 1D encodes a novel drug target in Hedgehog-GLI driven cancers and tumor-initiating cells resistant to SMO inhibition

This study identifies CSNK1D as a novel therapeutic target in Hedgehog-GLI driven cancers, showing its inhibition reduces tumor-initiating cell growth in both SMO-sensitive and -resistant settings.

Identification of alkylsalicylic acids in Lentisk oil (Pistacia lentiscus L.) and cytotoxicity on Human Normal Dermal Fibroblasts

This study identifies alkylsalicylic acids in Lentisk oil and evaluates their cytotoxicity on human dermal fibroblasts to assess safety as a cosmetic ingredient.

Aging selectively dampens oscillation of lipid abundance in white and brown adipose tissue

This study shows aging reduces lipid oscillations in adipose tissues, with BAT showing specific acyl chain length-dependent rhythms lost in older mice.

Membrane-Interactive Compounds from Pistacia lentiscus L. Thwart Pseudomonas aeruginosa Virulence

This study identifies ginkgolic acid and hydroginkgolic acid from Pistacia lentiscus L. as membrane-interactive compounds that inhibit Pseudomonas aeruginosa virulence by disrupting pyocyanin production and membrane homeostasis.

Genetic, cellular and structural characterization of the membrane potential-dependent cell-penetrating peptide translocation pore

This study identifies potassium channels that modulate CPP translocation by lowering transmembrane potential, revealing a mechanism involving megapolarization and water pore formation.

Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a novel macromolecular assembly

This paper determines the atomic structures of the C. difficile binary toxin CDTb using cryoEM and X-ray crystallography, revealing novel di-heptamer forms and critical domains for toxicity and stability.