Full-length NLRP3 forms oligomeric cages to mediate NLRP3 sensing and activation
L. Andreeva, L. David, S. Rawson, C. Shen, T. Pasricha, P. Pelegrin, H. Wu
This study identifies full-length NLRP3 as a membrane-localized oligomeric cage that senses stimuli and activates the inflammasome, distinct from other monomeric inflammasome sensors.
bioRxiv · Sep 12, 2021Immunology