Author

P. Pelegrin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Penin-Franch· 2 shared C. Molina-Lopez· 2 shared L. Hurtado-Navarro· 2 shared A. Baroja-Mazo· 1 shared A. I. Gomez· 1 shared A. I. Gomez-Sanchez· 1 shared A. Tapia-Abellan· 1 shared C. M. Martinez· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersImmunology

A. Penin-Franch

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Soluble P2X7 receptor is elevated in the plasma of COVID-19 patients and correlates with disease severity

J. Garcia-Villalba, L. Hurtado-Navarro, A. Penin-Franch, C. Molina-Lopez, L. Martinez-Alarcon, D. Angosto-Bazarra, A. Baroja-Mazo, P. Pelegrin

This study finds elevated soluble P2X7 receptor in COVID-19 patient plasma, correlating with disease severity but not IL-18 levels.

bioRxiv · Mar 4, 2022 · PreprintImmunology

Ornithine Lipid is a Partial TLR4 Agonist and NLRP3 Activator

M. Pizzuto, L. Hurtado-Navarro, C. Molina-Lopez, J. Soubhye, M. Gelbcke, S. Rodriguez-Lopez, J.-M. Ruysschaert, K. Schroder, P. Pelegrin

This study identifies ornithine lipid as a partial TLR4 agonist and NLRP3 activator, showing it can replace LPS in phosphate-depleted environments to trigger inflammation.

bioRxiv · Jan 28, 2022Immunology

Galvanic current activates the NLRP3 inflammasome to promote type I collagen production in tendon

A. Penin-Franch, J. A. Garcia-Vidal, C. M. Martinez, P. Escolar-Reina, A. I. Gomez, F. Minaya-Munoz, F. Valera-Garrido, F. Medina-Mirapeix, P. Pelegrin

This study shows galvanic current activates the NLRP3 inflammasome, promoting collagen production and tendon regeneration in chronic tendinopathies.

bioRxiv · Sep 20, 2021Immunology

Full-length NLRP3 forms oligomeric cages to mediate NLRP3 sensing and activation

L. Andreeva, L. David, S. Rawson, C. Shen, T. Pasricha, P. Pelegrin, H. Wu

This study identifies full-length NLRP3 as a membrane-localized oligomeric cage that senses stimuli and activates the inflammasome, distinct from other monomeric inflammasome sensors.

bioRxiv · Sep 12, 2021Immunology

ASC oligomer favor caspase-1CARD domain recruitment after intracellular potassium efflux

F. Martin-Sanchez, V. Compan, A. Tapia-Abellan, A. I. Gomez-Sanchez, M. C. Banos, F. I. Schmidt, P. Pelegrin

The paper shows that ASC oligomers change structure with low intracellular K+ to enhance caspase-1 recruitment, independent of NLRP3, and highlights K+ homeostasis as a key regulator of inflammasome activity.

bioRxiv · Jan 27, 2020Immunology