Optimizing linear ion trap data independent acquisition towards single cell proteomics
T. Phlairaharn, Z. Ye, E. Krismer, A.-K. Pedersen, M. Pietzner, J. V. Olsen, E. M. Schoof, B. C. Searle
This study optimizes linear ion trap data independent acquisition for single-cell proteomics, showing quantitative accuracy down to 0.5 ng on column using LIT-based libraries from as few as 40 cells.
bioRxiv · Feb 21, 2023Biochemistry