J. V. Olsen

Palaeoproteomic identification of a whale bone tool from Bronze Age Heiloo, the Netherlands

The paper identifies a Bronze Age bone tool from the Netherlands as North Atlantic right whale bone using palaeoproteomic methods and finds it was used for plant fibre processing.

Deciphering molecular mechanisms of synergistic growth reduction in kinase inhibitor combinations

This study investigates synergistic effects of kinase inhibitor combinations by analyzing phosphoproteomics and transcriptomics data to identify molecular mechanisms and pathway interactions.

Automated high-throughput biological sex identification from archaeological human dental enamel using targeted proteomics

This paper introduces a high-throughput proteomics method for biological sex identification from archaeological human dental enamel, achieving high accuracy and scalability.

STREAMLINED PROTEOME-WIDE IDENTIFICATION OF DRUG TARGETS INDICATES ORGAN-SPECIFIC ENGAGEMENT

The paper develops a proteomics method to identify drug targets across the proteome, revealing organ-specific interactions and global drug effects.

Phosphoproteomic investigation of targets of protein phosphatases in EGFR signaling

This study identifies phosphoproteomic targets of protein phosphatases in EGFR signaling using chemical inhibitors and mass spectrometry.

Multi-layered proteomics identifies insulin-induced upregulation of the EphA2 receptor via the ERK pathway and dependent on low IGF1R level

The paper uses multi-layered proteomics to show insulin increases EphA2 via ERK pathway, independent of insulin resistance, and dependent on low IGF1R levels.

One-Tip enables comprehensive proteome coverage in minimal cells and single zygotes

One-Tip provides a proteomics method for high-depth protein identification from minimal cell samples and single zygotes with high throughput.

Enamel proteins reveal biological sex and genetic variability within southern African Paranthropus

This study uses enamel proteomics to determine biological sex and assess intraspecific variation in Paranthropus robustus from South Africa, supporting the idea that morphological variation may reflect taxonomic diversity.

Matrix Gla Protein acts as a driver of stemness and tumor initiation in ovarian cancer

This study identifies Matrix Gla Protein (MGP) as a driver of stemness and tumor initiation in ovarian cancer by promoting Hedgehog signaling and enhancing tumor-initiating capacity.

Optimizing linear ion trap data independent acquisition towards single cell proteomics

This study optimizes linear ion trap data independent acquisition for single-cell proteomics, showing quantitative accuracy down to 0.5 ng on column using LIT-based libraries from as few as 40 cells.

Loss of N-terminal acetyltransferase A activity induces thermally unstable ribosomal proteins and increases their turnover

The paper shows that loss of Nt-acetylation in yeast leads to unstable ribosomal proteins and increased turnover.

Repurposing of Amisulpride, a known antipsychotic drug, to target synovial fibroblasts activation in arthritis.

This study identifies Amisulpride as a potential therapeutic for arthritis by reducing synovial fibroblast activation, independent of its known targets.

PRMT5-mediated regulatory arginine methylation of RIPK3

This study identifies PRMT5-mediated arginine methylation of RIPK3 as a feedback mechanism regulating RIPK1 activity and function in cell death pathways.

SPIN - Species by Proteome INvestigation

SPIN is a proteomics workflow that rapidly identifies over 150 mammalian species from samples using mass spectrometry, demonstrating effectiveness on degraded archaeological materials.

GHB confers neuroprotection by stabilizing the CaMKIIα hub domain

This study shows that GHB stabilizes the CaMKII hub domain, providing neuroprotection in cellular and mouse models.

A Compact Quadrupole-Orbitrap Mass Spectrometer with FAIMS Interface Improves Proteome Coverage in Short LC Gradients

Proteome and phosphoproteome changes associated with prognosis in acute myeloid leukemia

This study identifies proteome and phosphoproteome changes associated with AML relapse using patient samples and validates them with kinase inhibitors.

Rapid and site-specific deep phosphoproteome profiling by data-independent acquisition (DIA) without the need for spectral libraries

This paper introduces a DIA-based phosphoproteomics method that achieves high sensitivity and reproducibility without spectral libraries, demonstrating its scalability in analyzing kinase inhibitor effects on EGF signaling.

Protein aggregation capture on microparticles enables multi-purpose proteomics sample preparation

The paper introduces a proteomics sample preparation method using protein aggregation on microparticles, demonstrating its applicability to various proteomic analyses.

Limits for resolving tandem mass tag reporter ions with identical integer mass using phase constrained spectrum deconvolution

The paper determines the mass resolution limits for resolving TMT reporter ions with 0.0063 Da mass differences using an Orbitrap mass spectrometer.

A novel LC system embeds analytes in pre-formed gradients for rapid, ultra-robust proteomics

The paper introduces a novel LC system for proteomics that enables rapid, high-throughput, and robust analysis with deep proteome coverage.