Identification and characterization of novel proteins from Arizona bark scorpion venom that inhibit Nav1.8, a voltage-gated sodium channel regulator of pain signaling
T. M. Abd El-Aziz, Y. Xiao, J. Kline, H. Gridley, A. Heaston, K. D. Linse, M. J. Ward, D. R. Rokyta, J. D. Stockand, T. R. Cummins, L. Fornelli, A. H. Rowe
The paper identifies four novel scorpion venom proteins that inhibit Nav1.8, a sodium channel involved in pain signaling, through proteomic and electrophysiological analyses.
bioRxiv · Jun 24, 2021Pharmacology & Toxicology