The T Cell Receptor beta Chain Repertoire of Tumor Infiltrating Lymphocytes Improves Neoantigen Prediction and Prioritization
T. M. Q. Pham, T. N. Nguyen, B. Q. T. Nguyen, H. T. P. Nguyen, T. P. D. Tran, N. M. D. Pham, T. K. C. Ho, D. V. L. Nguyen, H. T. Nguyen, D. H. Tran, T. S. Tran, T.-V. N. Pham, M.-T. Le, T. T. V. Nguyen, M.-D. Phan, , L. S. Tran
This paper develops a machine learning model that integrates TCRβ and pHLA binding data to improve neoantigen prioritization in colorectal cancer, showing better performance than existing tools.
bioRxiv · Nov 16, 2023Cancer Biology