H.-N. Nguyen

Tissue of origin detection for cancer tumor using low-depth cfDNA samples through combination of tumor-specific methylation atlas and genome-wide methylation density in graph convolutional neural networks

The paper develops a model combining tumor-specific methylation atlas and cfDNA features to improve tissue-of-origin detection in low-depth cfDNA samples.

The T Cell Receptor beta Chain Repertoire of Tumor Infiltrating Lymphocytes Improves Neoantigen Prediction and Prioritization

This paper develops a machine learning model that integrates TCRβ and pHLA binding data to improve neoantigen prioritization in colorectal cancer, showing better performance than existing tools.

Improvement in Neoantigen Prediction via Integration of RNA Sequencing Data for Variant Calling

This study improves neoantigen prediction by integrating RNA sequencing data with DNA sequencing to identify more immunogenic neoantigens in colorectal cancer patients.

LRRC8A anion channels modulate vasodilation via association with Myosin Phosphatase Rho Interacting Protein (MPRIP)

This study shows LRRC8A anion channels interact with MPRIP to regulate vascular relaxation and inflammation through redox-dependent cytoskeletal changes.

Oxidant-Resistant LRRC8A/C Anion Channels Support Superoxide Production by Nox1

This study shows that LRRC8A/C anion channels regulate Nox1-mediated superoxide production and TNF signaling in vascular smooth muscle cells, with LRRC8C being more resistant to oxidants than LRRC8D.