Author

T. Sillo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

A. D. Beggs· 1 shared A. Stodolna· 1 shared C. Bryer· 1 shared C. M. Whalley· 1 shared C. Yau· 1 shared J. D. Barros-Silva· 1 shared J. D. Stockton· 1 shared K. Wanigasooriya· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

A. D. Beggs

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1 paper

Recent·Most cited

Patient derived organoids reveal that PI3K/AKT signaling is an escape pathway for radioresistance and a target for therapy in rectal cancer.

K. Wanigasooriya, J. D. Barros-Silva, L. Tee, M. E. Elasrag, A. Stodolna, O. Pickles, J. D. Stockton, C. Bryer, R. Hoare, C. M. Whalley, R. Tyler, T. Sillo, C. Yau, T. Ismail, A. D. Beggs

The paper identifies PI3K/AKT/mTOR pathway upregulation as a mechanism of radioresistance in rectal cancer and shows that dual PI3K/mTOR inhibitors radiosensitize cancer cells in organoid models.

bioRxiv · Aug 31, 2021 · PreprintCancer Biology