T. Volk

Sedentary behavior may accelerate aging through impact on epigenome and transcriptome: lessons from muscle inactivation in Drosophila larvae

This study shows that muscle inactivation in Drosophila larvae alters chromatin epigenetic balance and downregulates genes related to longevity and metabolism.

Regulation of chromatin microphase separation by adsorbed protein complexes

The paper models chromatin organization as a multiblock copolymer and shows that protein binding regulates its microphase separation.

The LINC complex inhibits excessive chromatin repression

The paper shows that the LINC complex prevents excessive chromatin repression by restricting repressive H3K27me3 clusters and maintaining RNA-Pol II binding to muscle genes.

Mesoscale phase separation of chromatin in the nucleus

The paper uses intact-organism imaging of Drosophila larvae to show chromatin phase separation and demonstrates a polymeric model explains the observed nuclear organization transitions.

Live imaging of chromatin distribution in muscle nuclei reveals novel principles of nuclear architecture and chromatin compartmentalization

The paper uses live imaging to show that chromatin forms a peripheral layer in Drosophila muscle nuclei, revealing a new model of nuclear architecture and chromatin compartmentalization.

Mechanosensitive recruitment of BAF to the nuclear membrane inhibits nuclear E2F1 and Yap levels

This study identifies BAF as a mechanosensitive factor that inhibits nuclear E2F1 and Yap levels by regulating their entry into the nucleus in Drosophila muscle fibers.

In vivo imaging of myonuclei during spontaneous muscle contraction reveals non-uniform nuclear mechanical dynamics in Nesprin/klar mutants

The paper uses in vivo imaging to study myonuclear mechanics in Drosophila larvae, finding increased variability in nuclear dynamics in Nesprin/klar mutants during muscle contractions.