T. Warnecke

Deep conservation of histone variants in Thermococcales archaea

The paper investigates the conservation and evolution of histone variants in Thermococcales archaea, finding deep conservation of HTkA- and HTkB-like histones and suggesting convergent evolution with eukaryotes.

Growth temperature is the principal driver of chromatinization in archaea

This study identifies growth temperature as the main factor influencing chromatinization in archaea by analyzing NAP diversity and abundance across 19 species.

Conserved Cdk inhibitors show unique structural responses to tyrosine phosphorylation

The paper uses molecular dynamics simulations to compare structural changes in Cyclin/Cdk/CKI trimers due to tyrosine phosphorylation in CKIs and their impact on Cdk activity.

Slaying the last unicorn - discovery of histones in the microalga Nanochlorum eucaryotum

The paper re-examines the presence of histones in the microalga Nanochlorum eucaryotum, finding evidence for histone proteins and nucleosomal structures, contradicting earlier reports.

Histone variants in archaea and the evolution of combinatorial chromatin complexity

This study investigates archaeal histone paralogs, showing they can form hetero-oligomeric complexes with distinct properties and have evolved conserved functional roles, suggesting combinatorial chromatin complexity predates eukaryotes.

The DNA-binding protein HTa from Thermoplasma acidophilum is an archaeal histone analog

The paper identifies HTa, a DNA-binding protein in Thermoplasma acidophilum, as an archaeal histone analog through chromatin architecture analysis.

Non-random inversion landscapes in prokaryotic genomes are shaped by heterogeneous selection pressures

The paper shows that inversion landscapes in prokaryotic genomes are biased towards symmetric inversions around the origin-terminus axis, but this bias varies across clades and is linked to adaptive genome architecture features.

The genetic basis and evolution of red blood cell sickling in deer

This study identifies the genetic basis of erythrocyte sickling in deer, revealing structural and evolutionary differences from human sickle cell disease.

Mobile introns shape the genetic diversity of their host genes

The paper shows that mobile introns drive genetic diversity in fungal genes by creating non-random patterns of single nucleotide polymorphisms near intron-exon boundaries.