Author

A. R. Barr

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 4 Organism:human· 4 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. Bakal· 2 shared T. Ly· 2 shared A. Crncec· 1 shared A. I. Lamond· 1 shared A. J. Wiecek· 1 shared A. Kar· 1 shared A. M. Redmond· 1 shared A. T. Lun· 1 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

C. Bakal

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Cell overgrowth during G1 arrest triggers an osmotic stress response and chronic p38 activation to promote cell cycle exit

L. Crozier, R. Foy, R. Adib, M. Badonyi, A. Kar, J. A. Holt, R. Wilson, C. Regnault, P. Whitfield, J. A. Marsh, A. T. Saurin, A. R. Barr, T. Ly

The paper shows that CDK4/6 inhibitor-induced G1 arrest causes cell overgrowth, triggering osmotic stress and p38-p53-p21 signaling to promote cell cycle exit.

bioRxiv · Sep 8, 2022Cell Biology

Genomic hallmarks and therapeutic implications of G0 cell cycle arrest in cancer

A. J. Wiecek, S. J. Cutty, D. Kornai, M. Parreno-Centeno, L. E. Gourmet, G. Malagoli Tagliazucchi, D. H. Jacobson, P. Zhang, L. Xiong, G. L. Bond, A. R. Barr, M. Secrier

This study identifies genomic features of G0 cell cycle arrest in cancer and links it to therapy resistance using transcriptomic analysis and machine learning.

bioRxiv · Nov 12, 2021 · PreprintCancer Biology

Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p27

B. R. Pennycook, A. R. Barr

This study shows CDK4/6 inhibitors can induce cell cycle arrest without needing p21 or p27, clarifying their mechanism and implications for cancer treatment.

bioRxiv · May 6, 2021Cell Biology

Conserved Cdk inhibitors show unique structural responses to tyrosine phosphorylation

J. B. Swadling, T. Warnecke, K. L. Morris, A. R. Barr

The paper uses molecular dynamics simulations to compare structural changes in Cyclin/Cdk/CKI trimers due to tyrosine phosphorylation in CKIs and their impact on Cdk activity.

bioRxiv · Feb 4, 2021Cell Biology

Cyclin A triggers Mitosis either via Greatwall or Cyclin B

N. Hegarat, A. Crncec, M. F. Suarez Peredo Rodriguez, F. Echegaray Iturra, Y. Gu, P. F. Lang, A. R. Barr, C. Bakal, M. T. Kanemaki, A. I. Lamond, B. Novak, T. Ly, H. Hochegger

This study shows Cyclin A can trigger mitosis through Greatwall or Cyclin B by regulating Cdk1 activity and phosphorylation of mitotic substrates.

The EMBO Journal · Apr 30, 2020Peer-reviewedCell Biology

A high-content RNAi screen reveals multiple roles for long noncoding RNAs in cell division

L. Stojic, A. T. Lun, P. Mascalchi, C. Ernst, A. M. Redmond, J. Mangei, A. R. Barr, V. Bousgouni, C. Bakal, J. C. Marioni, D. T. Odom, F. Gergely

A high-content RNAi screen identifies lncRNAs involved in cell division, revealing linc00899's role in regulating microtubule dynamics through suppression of TPPP/p25.

bioRxiv · Jul 19, 2019Cell Biology