Enhanced stability of the SARS CoV-2 spike glycoprotein trimer following modification of an alanine cavity in the protein core.
P. Poumbourios, C. Langer, I. Boo, T. Zakir, R. J. Center, A. Akerman, V. Milogiannakis, A. Aggarwal, S. G. Turville, H. E. Drummer
This paper modifies the SARS-CoV-2 spike protein to enhance thermal stability and neutralizing antibody response against ancestral and Delta variants, but reduced effectiveness against Omicron BA.1.
bioRxiv · Nov 8, 2022 · PreprintMicrobiology