A. Aggarwal

Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation

This paper describes the structure and function of M.BceJIV, a DNA methyltransferase in Burkholderia cenocepacia, showing it binds two DNA sequences simultaneously for methylation.

Machine Learning Elucidates Design Features of Plasmid DNA Lipid Nanoparticles for Cell Type-Preferential Transfection

This study uses machine learning to identify LNP composition parameters that enhance transfection efficiency across cell types and modulate cell type-preferentiality.

TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2

The paper shows Omicron SARS-CoV-2 lineages rely on ACE2 without TMPRSS2 complexes for entry, due to changes in the ACE2 Collectrin-Like Domain affecting TMPRSS2 activation.

A 3D microtumour system that faithfully represents ovarian cancer minimal residual disease

This paper develops a 3D microtumour system that mimics ovarian cancer minimal residual disease, showing it responds to chemotherapy and reflects molecular signatures of MRD.

Glycoprotein VI is Critical for the Detection and Progression of Abdominal Aortic Aneurysms

This study identifies glycoprotein VI as a critical factor in AAA detection and progression, showing its predictive value in humans and therapeutic potential in mice.

An engineered biosensor enables dynamic aspartate measurements in living cells

This paper develops a GFP-based biosensor to dynamically measure aspartate levels in living cells, showing it correlates with mass spectrometry measurements and detects temporal changes in aspartate concentration.

Dysregulated Platelet Function in Patients with Post-Acute Sequelae of COVID-19

This study examines platelet function and thrombotic risk in PASC patients, finding dysregulated platelet responses and reduced thrombosis under shear conditions.

Melanocytes Exhibit Distinct Cell States Governed by A Gene Regulatory Network Under Stochastic Influence

The paper identifies distinct melanocyte states and shows stochastic gene expression and epigenetic modification enable their co-existence and response to environmental cues.

P-Selectin promotes SARS-CoV-2 interactions with platelets and the endothelium

This study identifies P-selectin as a novel SARS-CoV-2 spike receptor that promotes viral interactions with platelets and endothelium, facilitating viral localization in airway capillaries.

A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein

This paper discovers a macrocyclic peptide that inhibits SARS-CoV-2 and related sarbecoviruses by targeting a conserved site in the spike protein, offering a potential broad-spectrum antiviral.

Enhanced stability of the SARS CoV-2 spike glycoprotein trimer following modification of an alanine cavity in the protein core.

This paper modifies the SARS-CoV-2 spike protein to enhance thermal stability and neutralizing antibody response against ancestral and Delta variants, but reduced effectiveness against Omicron BA.1.

Cellular, Molecular, and Enzymatic Signatures ofThrombi are Vascular Bed-Dependent

This study compares cellular and enzymatic features of arterial and venous thrombi from different vascular beds, finding distinct molecular profiles and enzyme activities linked to vascular remodeling.

Fibroblast-expressed LRRC15 suppresses SARS-CoV-2 infection and controls antiviral and antifibrotic transcriptional programs.

This study identifies LRRC15 as a host factor that suppresses SARS-CoV-2 infection and regulates antiviral and antifibrotic transcriptional programs in fibroblasts.

A sensitive and specific genetically encodable biosensor for potassium ions

The paper describes the development of a genetically encoded fluorescent K+ biosensor, GINKO2, optimized for sensitivity and specificity in vivo across multiple species.

Mechanistic Insights into the Effects of Key Mutations on SARS-CoV-2 RBD-ACE2 Binding

This study examines how key mutations in SARS-CoV-2 RBD affect binding to ACE2 using molecular dynamics simulations and free energy calculations, finding increased binding affinities in mutated variants.

Discovery of Antiviral Cyclic Peptides Targeting the Main Protease of SARS-CoV-2 via mRNA Display

This study identifies cyclic peptides targeting SARS-CoV-2 main protease using mRNA display, showing antiviral activity in vitro.

Neutralising antibodies against the SARS-CoV-2 Delta variant induced by Alhydroxyquim-II-adjuvanted trimeric spike antigens

This study shows that Alhydroxiquim-II-adjuvanted trimeric spike antigens induce high-titre, cross-variant neutralising antibodies against SARS-CoV-2 in animal models.

Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein using mRNA Display

The paper identifies cyclic peptide ligands to the SARS-CoV-2 spike protein RBD using mRNA display, finding six high-affinity molecules with nanomolar dissociation constants.

Temporal resolution of melanogenesis determine fatty acid metabolism as key skin pigment regulator

The paper identifies fatty acid metabolism as a key regulator of melanogenesis by analyzing temporal metabolic and transcriptional changes in melanocytes.

Ageing impairs the airway epithelium defence response to SARS-CoV-2

This study investigates age-related differences in the nasal epithelium's response to SARS-CoV-2, finding that older adults have impaired host defense and lower viral load due to reduced host machinery expression.

Potent in vitro anti-SARS-CoV-2 activity by gallinamide A and analogues via inhibition of cathepsin L

A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilizing immunity against SARS-CoV-2 infection in mice

A BCG-adjuvanted vaccine provides sterilizing immunity against SARS-CoV-2 in mice, with high neutralizing antibody titers and Th1 responses.

Hypercholesterolemia Impairs Clearance of Extracellular DNA and Promotes Inflammation and Atherosclerotic Plaque Progression

This study shows hypercholesterolemia impairs DNA clearance by reducing DNase activity, leading to inflammation and atherosclerosis progression in mice and humans.

A Sec14-like Phosphatidylinositol Transfer Protein Paralog Defines a Novel Class of Heme-binding Proteins With An Unusual Heme Coordination Mechanism

The paper identifies Sfh5 as a novel heme-binding protein with an unusual coordination mechanism, distinct from its Sec14-like PITP family members.

Integrated role of microRNA-30e-5p through targeting negative regulators of innate immune pathways during HBV infection and SLE

This study identifies miR-30e as a master regulator of innate immune responses during HBV infection and SLE, showing its role in modulating immune pathways and therapeutic potential.

HIV corruption of the Arp2/3-Cdc42-IQGAP1 axis to hijack cortical F-Actin to promote cell-cell viral spread.

The paper identifies HIV's manipulation of the Arp2/3-Cdc42-IQGAP1 pathway to hijack cortical F-Actin for cell-cell viral spread, showing that this process prevents particle release but enables infection through maturation of contacts.

Beyond Autoantibodies: Biological Roles Of Human Autoreactive B Cells In Rheumatoid Arthritis Revealed By Whole Transcriptome Profiling

This study identifies novel roles of autoreactive B cells in RA through transcriptome profiling, revealing potential therapeutic targets and mechanisms.