Rescue of the increased susceptibility to Mild Chronic Oxidative Stress of iNeurons carrying the MAPT Chromosome 17q21.3 H1/H1 risk allele by FDA-approved compounds
Eldem Sadikoglou, Daniel Domingo‐Fernándéz, Natalia Savytska, Noémia Fernandes, Patrizia Rizzu, Anastasia Illarionova, Tabea Strauß, Sigrid C. Schwarz, Alpha Tom Kodamullil, Günter U. Höglinger, Ashutosh Dhingra, Thomas Gasser, Peter Heutink
The paper investigates how the H1/H1 risk allele at the MAPT locus increases susceptibility to mild chronic oxidative stress in iNeurons and identifies FDA-approved compounds that rescue this vulnerability.
Cell Death and Disease · Nov 13, 2025Peer-reviewedNeuroscience