Cell BiologybioRxivPreprint
Pathogenic human huntingtin expression causes prolific intramuscular aggregation, leading to nuclear, metabolic, and physiological dysregulation in striated muscle.
Tadrs A. Hana, Kiel G. Ormerod
This study shows that pathogenic huntingtin in Drosophila muscle causes protein aggregation, nuclear and mitochondrial dysfunction, and impaired neuromuscular performance without overt structural changes.
DOI 10.64898/2026.04.20.719674