X Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels
Juan Song, Adrian Janiszewski, Natalie De Geest, Lotte Vanheer, Irene Talón, Mouna El Bakkali, Taeho Oh, Vincent Pasque
This study shows that X-chromosome dosage in mouse iPSCs affects chromatin accessibility, transcriptome, growth, and pluripotency exit, largely independent of DNA methylation.
Stem Cell Reports · Jan 10, 2019Peer-reviewedDevelopmental Biology