Author

Irene Talón

Leuven Stem Cell InstituteORCID 0000-0002-5800-5555Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Adrian JaniszewskiiD· 2 shared Juan SongiD· 2 shared Lotte VanheeriD· 2 shared Natalie De Geest· 2 shared Vincent PasqueiD· 2 shared Ayla Smout· 1 shared Burak ToprakhisariD· 1 shared Caterina Provenzano· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersDevelopmental Biology

Adrian JaniszewskiORCID

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3 papers

Recent·Most cited

Developmental BiologyCell Death and DiseasePeer-reviewedJan 14, 2021

PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells

Jonathan De Smedt, Elise Anne van Os, Irene Talón…·Catherine M. Verfaillie

The paper introduces a computational tool to identify key transcription factors in lineage specification and validates PU.1 as a master regulator for generating LSEC-like cells from pluripotent stem cells.

39 citations

humanscRNA-seq

𝕏 PostBluesky

Developmental BiologybioRxivFeb 9, 2019

Dynamic Erasure of Random X-Chromosome Inactivation during iPSC Reprogramming

Adrian Janiszewski, Irene Talón, Joel Chappell…·Vincent Pasque

This study investigates the dynamics of X-chromosome reactivation during mouse iPSC reprogramming, revealing hierarchical gene activation patterns and the role of chromatin regulators.

57 citations

mousebulk RNA-seq

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Developmental BiologyStem Cell ReportsPeer-reviewedJan 10, 2019

X Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels

Juan Song, Adrian Janiszewski, Natalie De Geest…·Vincent Pasque

This study shows that X-chromosome dosage in mouse iPSCs affects chromatin accessibility, transcriptome, growth, and pluripotency exit, largely independent of DNA methylation.

43 citations

mousebulk RNA-seq

𝕏 PostBluesky