Adrian Janiszewski

The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency

This study shows that Wnt/TCF7L1 repression promotes primitive endoderm differentiation in mESCs by inhibiting naive and formative pluripotency factors.

Predicting the Key Regulators of Cell Identity in Human Adult Pancreas

The paper reconstructs gene regulatory networks in human adult pancreatic cell types and identifies key transcription factors regulating cell identity.

Autologous micrograft accelerates endogenous wound healing response via ERK-induced cell migration

This study shows that autologous micrograft therapy accelerates wound healing by enhancing fibroblast migration through ERK pathway activation and increased matrix metalloproteinase activity.

Dynamic Erasure of Random X-Chromosome Inactivation during iPSC Reprogramming

This study investigates the dynamics of X-chromosome reactivation during mouse iPSC reprogramming, revealing hierarchical gene activation patterns and the role of chromatin regulators.

X Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation Levels

This study shows that X-chromosome dosage in mouse iPSCs affects chromatin accessibility, transcriptome, growth, and pluripotency exit, largely independent of DNA methylation.