Spatial isoform sequencing at sub-micrometer single-cell resolution reveals novel patterns of spatial isoform variability in brain cell types
Lieke Michielsen, Andrey D. Prjibelski, Careen Foord, Yelizaveta Spiegelman, Taewoo Kim, Wen Hu, Julien Jarroux, Justine Hsu, Rebecca Pfeil, Xinyi Zhang, Li Gan, Alexandru Ioan Tomescu, Iman Hajirasouliha, Hagen Tilgner
The paper develops a high-resolution spatial long-read sequencing method and software to analyze isoform variability in brain cell types, revealing both region-specific and cell-type-specific patterns.
bioRxiv · Jun 25, 2025 · PreprintNeuroscience