Author

Xinyi Zhang

Central China Normal University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Neuroscience· 4 Cell Biology· 2 Biophysics· 1 Evolutionary Biology· 1 Genetics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Approach:statistical model· 4 Research Focus:cell type annotation· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

Wei LiuiD· 2 shared Alexandru Ioan TomescuiD· 1 shared Andrey D. PrjibelskiiD· 1 shared Benjamin J. LeschiD· 1 shared Bo ZhangiD· 1 shared Careen FoordiD· 1 shared Chao NingiD· 1 shared Chen Chen· 1 shared

Activity by Year

2025-2026 · peak 7/yr

Co-Author Collaboration Network

10 top collaborators · 5 mutual co-author links

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2 shared papersNeuroscience

Wei LiuORCID

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Author profile →

10 papers

Recent·Most cited

Self-other value alignment shapes sustainable decisions

Wei Liu, Hongxiao Li, CHEN Ruixin, Jingwen Xu, Xinyi Zhang, Jiang Qiu, Xiaojun Sun

The paper investigates how self-other value alignment influences sustainable decisions through computational modeling, neuroimaging, and behavioral experiments.

bioRxiv · Oct 13, 2026 · PreprintNeuroscience

Genetic regulation of circulating metabolome in cattle

Jun Teng, Houcheng Li, Jian Yang, Jingsheng Lu, Chongwei Duan, Zhujun Chen, Xinyi Zhang, Xiuxin Zhao, Fen Pei, Xiaoping Wu, Pengju Zhao, Haihan Zhang, Hongding Gao, Lewei Guo, Dan Wang, , Xiao Wang

The paper presents a cattle metabolome atlas linking genetic variants to metabolites and traits, revealing colocalization with eQTL and causal gene-metabolite-trait networks.

bioRxiv · Sep 11, 2026 · PreprintGenetics

Foxp4+ Mandibular Skeletal Stem Cells Orchestrate Bone/Tooth Development and Regeneration

L J Zhang, Dandan Cao, X Li, Hongqiang Yu, Jianfang Wang, Qiaoling Zhu, Xinyi Zhang, Chen Chen, Gongchen Li, Xinyu Xu, Xiaoqiao Xu, Dike Tao, Xuyan Gong, Pingping Niu, XC Wu, , Yao Sun

This study identifies Foxp4+ mandibular skeletal stem cells (mdSSCs) that drive bone/tooth development and regeneration, showing their therapeutic potential in regenerating mandibular structures.

bioRxiv · May 1, 2026 · PreprintCell Biology

Combinatorial base editing couples disease correction with lineage amplification in hematopoietic stem and progenitor cells

Kun Jia, Eric Soupène, Roshani Sinha, Benjamin J. Lesch, Michael A. Pendergast, Rachel Choi, Xinyi Zhang, Elisabetta Manuela Foppiani, Zachary Kostamo, Simon N. Chu, Devesh Sharma, Xinjie Yu, Marco Cordero, Mark C. Walters, Tippi C. MacKenzie, , M. Kyle Cromer

This paper develops a combinatorial base editing strategy to enhance erythroid lineage amplification and disease correction in hematopoietic stem and progenitor cells.

bioRxiv · Apr 14, 2026 · PreprintCell Biology

The orbitofrontal cortex constructs allocentric schemas by integrating dynamic mobile agents with static environmental anchors

Ziyan Zhu, Bo Zhang, Xinyi Zhang, Yuji Naya

The paper shows the orbitofrontal cortex integrates dynamic agents and static anchors to form allocentric spatial schemas using fMRI and virtual reality.

bioRxiv · Mar 3, 2026 · PreprintNeuroscience

Non-invasive brain stimulation biases temporal value-aversiveness computations and promotes sustainable decision-making

Xinyi Zhang, Wei Liu

This study uses non-invasive brain stimulation to shift decision-making toward sustainability by altering value-aversiveness computations.

bioRxiv · Mar 2, 2026 · PreprintNeuroscience

A Bear-Specific Coding Exon in TMEM41B Is Associated with Cold Adaptation

Shuang Zhang, Hui Wang, Xinyi Zhang, Xiaodan Lu, Yu Xu, Kexin Xu, Jiaqi Zhang, Yijia Chen, Yonghao Feng, Yuru Wang, Yan Liu, Peglai Zou, Hanyin Zhang, Jiajun Yao, Yue Ma, , Xingxing Kong

The paper identifies a bear-specific coding exon in TMEM41B linked to cold adaptation through comparative genomics and functional analysis.

bioRxiv · Jan 14, 2026 · PreprintEvolutionary Biology

A Hybridization-Based Novel DNA Storage Technology with Rapid Read Performance

Yifei Zhang, Lijia Jia, XiaoXia WANG, Yue Shi, Haihua Wang, Dongyi Zhang, Pengfei Cheng, Ye Zhao, Mingyuan Xu, Xinyi Zhang, Zuying Xiao, Lei Wu, Xianghong Zhou, Di Liu

This paper proposes a hybridization-based DNA storage method that achieves rapid read speeds and high parallelism, validated through experiments on short-text storage and error correction.

bioRxiv · Dec 25, 2025 · PreprintSynthetic Biology

ANUBI: A Platform for Affinity Optimization of Proteins and Peptides in Drug Design

Damiano Buratto, Wanding Wang, Xinyi Zhang, Qiujie Zhu, Jia Meng, Daniel John Rigden, Ruhong Zhou, Francesco Zonta

ANUBI optimizes protein and peptide drug candidates by simulating sequence space and binding affinity calculations, improving target binding efficiency and reducing costs.

Journal of Chemical Theory and Computation · Dec 16, 2025Peer-reviewedBiophysics

Spatial isoform sequencing at sub-micrometer single-cell resolution reveals novel patterns of spatial isoform variability in brain cell types

Lieke Michielsen, Andrey D. Prjibelski, Careen Foord, Yelizaveta Spiegelman, Taewoo Kim, Wen Hu, Julien Jarroux, Justine Hsu, Rebecca Pfeil, Xinyi Zhang, Li Gan, Alexandru Ioan Tomescu, Iman Hajirasouliha, Hagen Tilgner

The paper develops a high-resolution spatial long-read sequencing method and software to analyze isoform variability in brain cell types, revealing both region-specific and cell-type-specific patterns.

bioRxiv · Jun 25, 2025 · PreprintNeuroscience