Sae2 antagonizes Rad9 accumulation at DNA double-strand breaks to attenuate checkpoint signaling and facilitate end resection
Tai-Yuan Yu, Michael T. Kimble, Lorraine S. Symington
This study shows Sae2 reduces Rad9 accumulation at DNA breaks, dampens checkpoint signaling, and promotes resection by competing with Rad9 for Tel1 binding.
Proceedings of the National Academy of Sciences · Dec 3, 2018Peer-reviewedGenetics