Lorraine S. Symington

The paper investigates how DNA double-strand breaks formed during replication are processed, finding asymmetrical resection and different requirements for repair pathways.

The paper investigates the role of residual cohesin in DNA double strand break repair during late mitosis, finding that cohesin reconstitutes but is not required for homologous recombination at the MAT locus.

The paper investigates the repair mechanism of replication-dependent double-strand breaks in budding yeast using nCas9-induced nicks and identifies the role of homologous recombination and replication-coupled nucleosome assembly.

The paper shows that DNA double-strand breaks near inverted repeats drive inverted duplications in Sae2 and Mre11-deficient cells through a mechanism involving DNA polymerase delta and Rad51.

This study shows that long-range DNA end resection by Exo1 and Sgs1-Dna2 supports homologous recombination through checkpoint activation, not by generating extensive homology.

The paper investigates recombination at stalled replication forks in yeast, showing it requires Rad51 and Rad52-Rad59 activities and is limited by Srs2 and Mus81-Mms4/Yen1.

This study identifies a distinct Mec1/ATR signaling mode triggered by DNA end hyper-resection, showing its role in regulating HR-mediated DNA repair through phosphorylation of the STR complex.

This study shows Sae2 reduces Rad9 accumulation at DNA breaks, dampens checkpoint signaling, and promotes resection by competing with Rad9 for Tel1 binding.

This study shows Xrs2 and Tel1 independently contribute to MR-mediated DNA tethering and replisome stability in yeast, with Tel1 stabilizing Mre11-DNA association and rescuing DNA damage resistance.