Michael T. Kimble

The paper investigates how DNA double-strand breaks formed during replication are processed, finding asymmetrical resection and different requirements for repair pathways.

The paper investigates the repair mechanism of replication-dependent double-strand breaks in budding yeast using nCas9-induced nicks and identifies the role of homologous recombination and replication-coupled nucleosome assembly.

This study shows that long-range DNA end resection by Exo1 and Sgs1-Dna2 supports homologous recombination through checkpoint activation, not by generating extensive homology.

This study shows Sae2 reduces Rad9 accumulation at DNA breaks, dampens checkpoint signaling, and promotes resection by competing with Rad9 for Tel1 binding.