A Disease-Associated Mutation Impedes PPIA Through Allosteric Dynamics Modulation
Yoshikazu Hattori, Munehiro Kumashiro, Hiroyuki Kumeta, Taisei Kyo, Soichiro Kawagoe, Motonori Matsusaki, Tomohide Saio
This study investigates how the K76E mutation in PPIA affects protein dynamics and function, finding that it impairs isomerase activity through allosteric network disruption rather than structural changes.
Biochemistry · Jun 30, 2025Peer-reviewedBiochemistry