Author

Munehiro Kumashiro

Institute of Advanced Medical Sciences, Tokushima UniversityORCID 0000-0002-8274-928XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Hiroyuki KumetaiD· 2 shared Motonori MatsusakiiD· 2 shared Soichiro KawagoeiD· 2 shared Tomohide SaioiD· 2 shared Do Thanh Tuan· 1 shared Eiichiro MoriiD· 1 shared Hettimudalige Dilini Nisansala· 1 shared Honoka Ota· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Hiroyuki KumetaORCID

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2 papers

Recent·Most cited

OptoChaperone - A biohybrid tool for regulating protein condensates in cells and in vitro

Do Thanh Tuan, Motonori Matsusaki, Honoka Ota, Soichiro Kawagoe, Hettimudalige Dilini Nisansala, Munehiro Kumashiro, Noriyoshi Isozumi, Hiroyuki Kumeta, Yohei Kono, Takeshi Shimi, Koichiro Ishimori, Eiichiro Mori, Satoshi Arai, Tomohide Saio

OptoChaperone enables reversible, spatiotemporal control of protein condensates using light, demonstrating efficacy in regulating disease-related condensates without chemical additives or genetic modifications.

Journal of the American Chemical Society · Apr 20, 2026Peer-reviewedBiochemistry

A Disease-Associated Mutation Impedes PPIA Through Allosteric Dynamics Modulation

Yoshikazu Hattori, Munehiro Kumashiro, Hiroyuki Kumeta, Taisei Kyo, Soichiro Kawagoe, Motonori Matsusaki, Tomohide Saio

This study investigates how the K76E mutation in PPIA affects protein dynamics and function, finding that it impairs isomerase activity through allosteric network disruption rather than structural changes.

Biochemistry · Jun 30, 2025Peer-reviewedBiochemistry