Author

Motonori Matsusaki

Institute of Advanced Medical Sciences, Tokushima UniversityORCID 0000-0002-7296-033XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 3 Research Focus:cell signaling & trafficking· 2 Assay:protein structure· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Organism:human· 1 Organism:yeast· 1

Frequent Co-Authors

Hiroyuki KumetaiD· 4 shared Tomohide SaioiD· 4 shared Eiichiro MoriiD· 3 shared Koichiro IshimoriiD· 2 shared Mai Watabe· 2 shared Masaki OkumuraiD· 2 shared Munehiro KumashiroiD· 2 shared Noriyoshi IsozumiiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersBiochemistry

Hiroyuki KumetaORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

OptoChaperone - A biohybrid tool for regulating protein condensates in cells and in vitro

Do Thanh Tuan, Motonori Matsusaki, Honoka Ota, Soichiro Kawagoe, Hettimudalige Dilini Nisansala, Munehiro Kumashiro, Noriyoshi Isozumi, Hiroyuki Kumeta, Yohei Kono, Takeshi Shimi, Koichiro Ishimori, Eiichiro Mori, Satoshi Arai, Tomohide Saio

OptoChaperone enables reversible, spatiotemporal control of protein condensates using light, demonstrating efficacy in regulating disease-related condensates without chemical additives or genetic modifications.

Journal of the American Chemical Society · Apr 20, 2026Peer-reviewedBiochemistry

Ca2+-driven PDIA6 phase separation to ensure proinsulin quality control

Young‐Ho Lee, Tomohide Saio, Mai Watabe, Motonori Matsusaki, Shingo Kanemura, Yuxi Lin, Taro Mannen, Tsubura Kuramochi, Yuka Kamada, Katsuya Iuchi, Michiko Tajiri, Kotono Suzuki, Yan Li, Yunseok Heo, Kotone Ishii, , Masaki Okumura

This study shows Ca2+ induces PDIA6 phase separation, enhancing proinsulin folding and preventing aggregation through recruitment of PDIA3.

Nature Cell Biology · Nov 1, 2025Peer-reviewedBiochemistry

A Disease-Associated Mutation Impedes PPIA Through Allosteric Dynamics Modulation

Yoshikazu Hattori, Munehiro Kumashiro, Hiroyuki Kumeta, Taisei Kyo, Soichiro Kawagoe, Motonori Matsusaki, Tomohide Saio

This study investigates how the K76E mutation in PPIA affects protein dynamics and function, finding that it impairs isomerase activity through allosteric network disruption rather than structural changes.

Biochemistry · Jun 30, 2025Peer-reviewedBiochemistry

Conserved loop of a phase modifier endows protein condensates with fluidity

Honoka Kawamukai, Motonori Matsusaki, Takanari Tanimoto, Mai Watabe, Ken Morishima, Shunsuke Tomita, Yoichi Shinkai, Tatsuya Niwa, Taro Mannen, Hiroyuki Kumeta, Hitoki Nanaura, Kotona Kato, Takuya Mabuchi, Yuichiro Aiba, Takeru Uehara, , Tomohide Saio

This study identifies Kapβ2 as a target of DPRs, showing how DPR binding alters its phase-modifying function, leading to toxic RBP condensates in ALS models.

bioRxiv · Jul 3, 2024 · PreprintBiochemistry