MHC class II in dopaminergic neurons prunes GABAergic synapses in neurodevelopmental disorders
Gen Murakami, Masataka Hirasaki, Miki Hashizume, Ayumi Hirao, Rina Ito, Yasushi Hojo, Takanari Nakano, Naonori Uozumi, Takayuki Murakoshi
This study shows MHC class II upregulation in dopaminergic neurons due to maternal immune activation leads to reduced GABAergic synapses and behavioral deficits.
bioRxiv · Sep 1, 2026 · PreprintNeuroscience