Dissipation of lysosome pH impairs formation and collapses existing LPS-induced lysosome tubules in macrophages
Shiraz Anwar, Solmaz Ebrahimi-Iranpour, Maria R. Narciso, Tamara Berilia, Saaimatul Huq, Tracy Linda Brittney Lackraj, Tamara Beriia, Nazia Chowdhury, Mojca Mattiazzi Ušaj, Roberto J. Botelho
This study shows that lysosome pH is critical for LPS-induced lysosome tubulation in macrophages, as alkalinizing pH blocks tubulation while maintaining mTORC1 activity.
Molecular Biology of the Cell · Oct 8, 2026Peer-reviewedCell Biology